VDR is a gene which encodes for a protein which acts as a receptor for vitamin D that regulates bone formation and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by the two components, and it is influenced by chromosomal locations and by binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes have an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online storage facility for data and documents pertinent to business, legal transactions or proceedings microsoft teams with restrictions on viewing or downloading. It is accessed via a central computer and an extranet which is a restricted access Internet connection that allows users to access the internet at specified times.

Companies involved in investment banking and in mergers and acquisitions are among the most common users of a VDR. They require a secure platform for sharing information with investors or potential buyers in a manner that is transparent, and the process of due diligence can require huge amounts of data. Life science companies also utilize VDRs to store everything from clinical trial results to HIPAA documentation.